Issue 37, 2012
From the journal:

Organic & Biomolecular Chemistry

Phosphine-catalyzed domino reaction: an efficient method for the synthesis of highly functionalized spirooxazolines†

Lihua Yang,a   Peizhong Xie,a   Erqing Li,a   Xin Li,a   You Huang*a  and  Ruyu Chena  

* Corresponding authors

a State Key Laboratory and Institute of Elemento-organic Chemistry Nankai University, Tianjin 300071, People's Republic of China
E-mail: hyou@nankai.edu.cn;
Fax: (+86) 22-23503627
Tel: (+86) 22-23503159

Abstract

A novel phosphine-catalyzed intermolecular [3 + 2] cycloaddition of ynones and N-substituted isatins was developed. In this reaction, substituted ynones, serving as a C3 synthon, were successfully applied in intermolecular annulation reactions. A number of functionalized spirooxazolines were obtained in high yields and stereoselectivity.

Graphical abstract: Phosphine-catalyzed domino reaction: an efficient method for the synthesis of highly functionalized spirooxazolines

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Article information

DOI
https://doi.org/10.1039/C2OB26338F
Article type
Paper
Submitted
25 Mar 2012
Accepted
01 Aug 2012
First published
02 Aug 2012

Org. Biomol. Chem., 2012,10, 7628-7634

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Phosphine-catalyzed domino reaction: an efficient method for the synthesis of highly functionalized spirooxazolines

L. Yang, P. Xie, E. Li, X. Li, Y. Huang and R. Chen, Org. Biomol. Chem., 2012, 10, 7628 DOI: 10.1039/C2OB26338F

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