Issue 48, 2012
From the journal:

Organic & Biomolecular Chemistry

Probing myo-inositol 1-phosphate synthase with multisubstrate adducts†

Rania M. Deranieh,a   Miriam L. Greenberg,a   Pierre-B. Le Calvez,b   Maura C. Mooneyc  and  Marie E. Migaud*bd  

* Corresponding authors

a College of Liberal Arts and Sciences, Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA

b Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK

c School of Chemistry and Chemical Engineering, Queen's University, Belfast, David Keir Building, Stranmillis Road, Belfast, NI, UK

d School of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
E-mail: m.migaud@qub.ac.uk

Abstract

The synthesis of a series of carbohydrate–nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.

Graphical abstract: Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

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Article information

DOI
https://doi.org/10.1039/C2OB26577J
Article type
Paper
Submitted
09 Aug 2012
Accepted
24 Oct 2012
First published
30 Oct 2012

Org. Biomol. Chem., 2012,10, 9601-9619

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Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

R. M. Deranieh, M. L. Greenberg, Pierre-B. Le Calvez, M. C. Mooney and M. E. Migaud, Org. Biomol. Chem., 2012, 10, 9601 DOI: 10.1039/C2OB26577J

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