The 3,3′-bioxindole derivatives were constructed in a single step via an efficient Rh2(OAc)4 catalyzed reaction of diazoacetamides with isatins. This novel method provides an alternative pathway towards 3-hydroxy-3,3′-bioxindoles in good yield (up to 78%) with high diastereoselectivity (up to 95 : 5).
M. Li, L. Zan, D. Prajapati and W. Hu, Org. Biomol. Chem., 2012, 10, 8808 DOI: 10.1039/C2OB26580J
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