Issue 44, 2012
From the journal:

Organic & Biomolecular Chemistry

Synthesis of functionalized 2-aryl-4-(indol-3-yl)-4H-chromenes via iodine-catalyzed domino Michael addition–intramolecular cyclization reaction†

Guodong Yin,*a   Ling Fan,a   Tianbing Ren,a   Chunyang Zheng,a   Qing Tao,a   Anxin Wub  and  Nengfang She*b  

* Corresponding authors

a Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, College of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi 435002, China
E-mail: gdyin@hbnu.edu.cn

b Key Laboratory of Pesticides and Chemical Biology of the Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China
E-mail: nfshe@mail.ccnu.edu.cn

Abstract

An efficient synthesis of novel functionalized 2-aryl-4-(indol-3-yl)-4H-chromenes has been developed, in the presence of a catalytic amount of iodine, from easily available starting materials, 2-hydroxychalcone derivatives. Indole, substituted indoles and 7-azaindole are suitable for this transformation. The possible domino Michael addition–intramolecular cyclization reaction mechanism is proposed.

Graphical abstract: Synthesis of functionalized 2-aryl-4-(indol-3-yl)-4H-chromenes via iodine-catalyzed domino Michael addition–intramolecular cyclization reaction

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2OB26642C
Article type
Paper
Submitted
17 Aug 2012
Accepted
24 Sep 2012
First published
24 Sep 2012

Org. Biomol. Chem., 2012,10, 8877-8883

Permissions

Request permissions

Synthesis of functionalized 2-aryl-4-(indol-3-yl)-4H-chromenes via iodine-catalyzed domino Michael addition–intramolecular cyclization reaction

G. Yin, L. Fan, T. Ren, C. Zheng, Q. Tao, A. Wu and N. She, Org. Biomol. Chem., 2012, 10, 8877 DOI: 10.1039/C2OB26642C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements