Formation of cyclodextrin-stabilized nanoemulsions and microemulsions and exploitation of their solubilization behavior

Abstract

This paper describes the formation and stability of cyclodextrin (CD) encapsulated micromulsions and nanoemulsions by a percolation and phase inversion temperature (PIT) emulsification method using AOT and Tween+lecithin as surfactants. The stability of the formulated system has been checked by visible absorption spectroscopy and particle size estimations. The results show that the particle size of the nanoemulsion increased slightly over a period of one month whereas the AOT based microemulsion has been reported to be stable over months. However, it was found that nanoemulsions form a better host for the assimilation of various CDs such as α-CD, β-CD and β-CD-hydrate whereas microemulsions have been reported to host hp-β-CD only. The study of interactions has been carried out using FTIR and fluorescence studies. The structural transitions within the microemulsions and nanoemulsions have also been studied with visible absorption spectroscopy.