Issue 27, 2012
From the journal:

RSC Advances

Synthesis of the C45–C53 tetrahydropyran domain of norhalichondrins and the C14–C22 tetrahydrofuran domain of the halichondrin family†

Gowravaram Sabitha,*a   Gajangi Chandrashekhar,a   Jhillu Singh Yadav,a   Kavitha Rachinenib  and  Bharatam Jagadeeshb  

* Corresponding authors

a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India
E-mail: gowravaramsr@yahoo.com
Fax: +91-40-27160512

b Nuclear Magnetic Resonance Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India

Abstract

Sequential asymmetric α-aminoxylation of aldehydes and Horner–Wadsworth–Emmons olefination has been used as the key reaction for the synthesis of the C45–C53 tetrahydropyran domain of norhalichondrins and C14–C22 tetrahydrofuran domain of halichondrin family.

Graphical abstract: Synthesis of the C45–C53 tetrahydropyran domain of norhalichondrins and the C14–C22 tetrahydrofuran domain of the halichondrin family

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Article information

DOI
https://doi.org/10.1039/C2RA21346J
Article type
Communication
Submitted
03 Jul 2012
Accepted
02 Sep 2012
First published
04 Sep 2012

RSC Adv., 2012,2, 10157-10159

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Synthesis of the C45–C53 tetrahydropyran domain of norhalichondrins and the C14–C22 tetrahydrofuran domain of the halichondrin family

G. Sabitha, G. Chandrashekhar, J. S. Yadav, K. Rachineni and B. Jagadeesh, RSC Adv., 2012, 2, 10157 DOI: 10.1039/C2RA21346J

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