Issue 33, 2012
From the journal:

RSC Advances

The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols†

Keiko Inami,*ab   Ikuo Nakanishi,c   Mine Morita,a   Miyuki Furukawa,a   Kei Ohkubo,d   Shunichi Fukuzumide  and  Masataka Mochizukiab  

* Corresponding authors

a Kyoritsu University of Pharmacy, Shibako-en 1-5-30, Minato-ku, Tokyo 105-8512, Japan

b Faculty of Pharmaceutical Sciences, Tokyo University of Science, Yamazaki 2641, Noda-shi, Chiba 278-8510, Japan
E-mail: inami@rs.noda.tus.ac.jp

c Research Center for Charged Particle Therapy, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba 263-8555, Japan

d Department of Material and Life Science, Graduate School of Engineering, Osaka University, ALCA, Japan Science and Technology Agency, Suita, Osaka 565-0871, Japan

e Department of Bioinspired Science, Ewha Womans University, Seoul 120-750, Korea

Abstract

The hydroxyl radical-scavenging activity of the amino-substituted α-tocopherol analogues was much higher than that of α-tocopherol. Aminochromanoxyl radicals generated from 5- and 7-aminochromanol were successfully detected in aqueous solution at room temperature during ESR measurements. The stability of the aminochromanoxyl radicals leads to a significant enhancement of the radical-scavenging activity.

Graphical abstract: The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C2RA21928J
Article type
Communication
Submitted
24 Aug 2012
Accepted
29 Oct 2012
First published
07 Nov 2012

RSC Adv., 2012,2, 12714-12717

Permissions

Request permissions

The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols

K. Inami, I. Nakanishi, M. Morita, M. Furukawa, K. Ohkubo, S. Fukuzumi and M. Mochizuki, RSC Adv., 2012, 2, 12714 DOI: 10.1039/C2RA21928J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements