Capping of oligonucleotides with “clickable” m3G-CAPs†
Abstract
The RNA components of small nuclear ribonucleoproteins (U snRNPs) possess a characteristic 5′-terminal 2,2,7-trimethyl-guanosine CAP structure (m3G-CAP). This cap is an important component of the nuclear localization signal of U snRNPs. Here we report synthesis of four m3G-CAP constructs and the effective attachment of these onto
- This article is part of the themed collections: A Decade of Progress in Click Reactions Based on CuAAC and Nucleic acids: new life, new materials