Issue 2, 2012

Aerobic oxidation of thiols to disulfides by heterogeneous goldcatalysts

Abstract

Thiols are smoothly and efficiently oxidized to disulfides (RSSR) with air in the presence of gold nanoparticles supported on CeO2 in absence of solvent, as well as in aqueous solutions and neutral pH. It is shown that the reaction can occur through the coupling of two sulphur radicals on the metal surface. The sulphur radicals are formed from thiols by one-electron oxidation with the metal. This reaction mechanism strongly resembles that found for sulfhydryl oxidases, a class of enzymes which are involved in the oxidative protein folding through de novo formation of disulfides from thiols.

Graphical abstract: Aerobic oxidation of thiols to disulfides by heterogeneous gold catalysts

Supplementary files

Article information

Article type
Edge Article
Submitted
14 Jul 2011
Accepted
08 Sep 2011
First published
18 Oct 2011

Chem. Sci., 2012,3, 398-404

Aerobic oxidation of thiols to disulfides by heterogeneous gold catalysts

A. Corma, T. Ródenas and M. J. Sabater, Chem. Sci., 2012, 3, 398 DOI: 10.1039/C1SC00466B

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