Issue 5, 2012
From the journal:

Chemical Science

Metal-free, aerobic ketooxygenation of alkenes using hydroxamic acids†

Valerie A. Schmidta  and  Erik J. Alexanian*a  

* Corresponding authors

a Department of Chemistry, The University of North Carolina at Chapel Hill, 101 South Road, Chapel Hill, North Carolina, USA
E-mail: eja@email.unc.edu
Fax: +1-919-962-2388
Tel: +1-919-962-4976

Abstract

A metal-free, radical-mediated alkene ketooxygenation is described. This four-electron alkene oxidation delivers α-oxyketones directly from simple alkenes with high levels of regio- and stereocontrol. The aerobic process capitalizes on the unique reactivity of amidoxyl radicals in intra- and intermolecular alkene additions.

Graphical abstract: Metal-free, aerobic ketooxygenation of alkenes using hydroxamic acids

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Article information

DOI
https://doi.org/10.1039/C2SC01042A
Article type
Edge Article
Submitted
09 Dec 2011
Accepted
02 Feb 2012
First published
03 Feb 2012

Chem. Sci., 2012,3, 1672-1674

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Metal-free, aerobic ketooxygenation of alkenes using hydroxamic acids

V. A. Schmidt and E. J. Alexanian, Chem. Sci., 2012, 3, 1672 DOI: 10.1039/C2SC01042A

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