Issue 11, 2013
From the journal:

Analyst

Simple and rapid detection of l-Dopa decarboxylase activity using gold nanoparticles†

So Young Park,ab   Dohyoung Kwon,a   Hyejung Mokac  and  Bong Hyun Chung*ab  

* Corresponding authors

a BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea
E-mail: chungbh@kribb.re.kr
Fax: +82-42-879-8594
Tel: +82-42-860-4442

b School of Engineering, University of Science and Technology (UST), P. O. Box 217, Gajungro, Yuseong-gu, Daejeon 305-600, Republic of Korea

c Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Republic of Korea

Abstract

We developed a new detection method for L-Dopa decarboxylase (DDC) activity using gold nanoparticles (AuNPs). When L-3,4-dihydroxyphenylalanine (L-Dopa) is decarboxylated to dopamine (DA) by DDC, DA induces the aggregation of AuNPs, and the color of the AuNPs changes from red to blue.

Graphical abstract: Simple and rapid detection of l-Dopa decarboxylase activity using gold nanoparticles

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Article information

DOI
https://doi.org/10.1039/C3AN00009E
Article type
Communication
Submitted
03 Jan 2013
Accepted
02 Apr 2013
First published
03 Apr 2013

Analyst, 2013,138, 3146-3149

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Simple and rapid detection of L-Dopa decarboxylase activity using gold nanoparticles

S. Y. Park, D. Kwon, H. Mok and B. H. Chung, Analyst, 2013, 138, 3146 DOI: 10.1039/C3AN00009E

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