Issue 21, 2013
From the journal:

Analyst

Ratiometric fluorescence imaging of cellular hypochlorous acid based on heptamethine cyanine dyes†

Zhangrong Lou,ab   Peng Li,a   Peng Songc  and  Keli Han*a  

* Corresponding authors

a State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS), 457 Zhongshan Road, Dalian 116023, P. R. China
E-mail: klhan@dicp.ac.cn
Fax: +86-411-84675584
Tel: +86-411-84379293

b University of Chinese Academy of Sciences, Beijing 100049, China

c Department of Physics, Liaoning University, Shenyang 110036, P. R. China

Abstract

A series of ratiometric probes based on heptamethine cyanine dyes for detecting hypochlorous acid have been developed. Here we present the synthesis, characterization and fluorescence properties of these probes. And it turns out that the probes are highly sensitive and selective toward hypochlorous acid. More importantly, the application in living cells for ratiometric imaging of hypochlorous acid has been achieved successfully.

Graphical abstract: Ratiometric fluorescence imaging of cellular hypochlorous acid based on heptamethine cyanine dyes

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Article information

DOI
https://doi.org/10.1039/C3AN00198A
Article type
Communication
Submitted
26 Jan 2013
Accepted
09 Aug 2013
First published
09 Aug 2013

Analyst, 2013,138, 6291-6295

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Ratiometric fluorescence imaging of cellular hypochlorous acid based on heptamethine cyanine dyes

Z. Lou, P. Li, P. Song and K. Han, Analyst, 2013, 138, 6291 DOI: 10.1039/C3AN00198A

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