Issue 21, 2013
From the journal:

Analyst

Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography†

Xiwei Zheng,a   Michelle J. Yooa  and  David S. Hage*a  

* Corresponding authors

a Department of Chemistry, University of Nebraska, Lincoln, NE, USA
E-mail: dhage1@unl.edu
Fax: +1-402-472-9402
Tel: +1-402-472-2744

Abstract

A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin.

Graphical abstract: Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography

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Article information

DOI
https://doi.org/10.1039/C3AN01315D
Article type
Communication
Submitted
09 Jul 2013
Accepted
21 Aug 2013
First published
21 Aug 2013

Analyst, 2013,138, 6262-6265

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Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography

X. Zheng, M. J. Yoo and D. S. Hage, Analyst, 2013, 138, 6262 DOI: 10.1039/C3AN01315D

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