Issue 23, 2013
From the journal:

Analyst

A novel and photostable pH probe for selectively staining nuclei in living cells†

Lintao Zeng,*ab   Ne Fan,b   Jiayu Zha,b   Xichao Hu,a   Boqiao Fu,a   Caiqin Qina  and  Liang Wang*b  

* Corresponding authors

a Department of Chemistry and Material Sciences, Hubei Engineering University, Xiaogan 432000, P. R. China
E-mail: zlt1981@126.com
Fax: +86 712 2345265

b School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China
E-mail: nkwangliang@yahoo.com.cn
Fax: +86 22 60214252

Abstract

A novel pH probe based on hemi-cyanine was synthesized, which displays extremely large Stokes shift (122 nm) and good photostability. The probe responds to basic pH (pKa 8.32) with a colorimetric and fluorescence turn-on signal. Interestingly, the probe has good cell membrane permeability and could selectively stain nuclei in living cells.

Graphical abstract: A novel and photostable pH probe for selectively staining nuclei in living cells

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Article information

DOI
https://doi.org/10.1039/C3AN01655B
Article type
Communication
Submitted
02 Sep 2013
Accepted
02 Oct 2013
First published
03 Oct 2013

Analyst, 2013,138, 7083-7086

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A novel and photostable pH probe for selectively staining nuclei in living cells

L. Zeng, N. Fan, J. Zha, X. Hu, B. Fu, C. Qin and L. Wang, Analyst, 2013, 138, 7083 DOI: 10.1039/C3AN01655B

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