Issue 16, 2013
From the journal:

Analytical Methods

Liquid crystal based sensors for the detection of cholic acid

Sihui He,a   Wenlang Liang,b   Colleen Tanner,b   Kung-Lung Cheng,c   Jiyu Fang*b  and  Shin-Tson Wu*a  

* Corresponding authors

a College of Optics and Photonics, University of Central Florida, Orlando, FL 32816, USA
E-mail: swu@creol.ucf.edu

b Department of Materials Science and Engineering, University of Central Florida, Orlando, FL 32816, USA
E-mail: jfang@mail.ucf.edu

c Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan

Abstract

The concentration level of cholic acid is a biomarker for the early diagnosis of liver and intestinal diseases. We present a biosensor platform based on the anchoring transition of 4-cyano-4′-pentylbiphenyl (5CB) liquid crystals at surfactant-laden 5CB/aqueous interfaces for the detection of cholic acid (CA) in aqueous solution. In the biosensor platform, the competitive adsorption of CA at the surfactant-laden 5CB/aqueous interfaces can trigger a homeotropic-to-planar anchoring transition of the 5CB at the interface, which can be easily observed using a polarizing optical microscope. We find that the detection limit of the 5CB based biosensors for CA depends on the pH and ionic strength of the aqueous phase and the headgroup of the surfactants.

Graphical abstract: Liquid crystal based sensors for the detection of cholic acid

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Article information

DOI
https://doi.org/10.1039/C3AY40733K
Article type
Paper
Submitted
02 May 2013
Accepted
17 Jun 2013
First published
08 Jul 2013

Anal. Methods, 2013,5, 4126-4130

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Liquid crystal based sensors for the detection of cholic acid

S. He, W. Liang, C. Tanner, K. Cheng, J. Fang and S. Wu, Anal. Methods, 2013, 5, 4126 DOI: 10.1039/C3AY40733K

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