Issue 22, 2013

MgF2–Au–MgF2-polydopamine based surface plasmon resonance sensor and its application in biomedical systems

Abstract

We report a MgF2–Au–MgF2-polydopamine based surface plasmon resonance (SPR) sensor and its biomedical applications. The symmetrical MgF2–Au–MgF2 geometry induced a minimum loss of surface plasmons leading to, so far, the best refractive index resolution of 2.2 × 10−8 refractive index units (RIU) in a glucose solution protocol. Meanwhile, a high detection performance could be maintained in the sensed medium with a refractive index ranging from 1.03 to 1.33 RIU. In order to solve the problem of surface functionalization on MgF2, which was thought to be inert, we managed to form adherent polydopamine films onto the MgF2–Au–MgF2 surface by dopamine self-polymerization, and found that secondary reactions could be used to create a variety of ad-layers for further biological uses. Finally, a model experiment on a chip detecting cellular mediators in human aqueous humor demonstrated the biomedical application of this system.

Graphical abstract: MgF2–Au–MgF2-polydopamine based surface plasmon resonance sensor and its application in biomedical systems

Article information

Article type
Paper
Submitted
12 Aug 2013
Accepted
10 Sep 2013
First published
10 Sep 2013

Anal. Methods, 2013,5, 6306-6311

MgF2–Au–MgF2-polydopamine based surface plasmon resonance sensor and its application in biomedical systems

Z. Liu, Q. Peng, H. Shi, S. Sun, J. Guo, X. Wang, L. Liu, Y. Ji, J. Guo, H. Ma and Y. He, Anal. Methods, 2013, 5, 6306 DOI: 10.1039/C3AY41380B

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