Issue 4, 2013
From the journal:

Biomaterials Science

Enhanced uptake of nanoparticledrug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line†

Samer R. Abulateefeh,ab   Sebastian G. Spain,a   Kristofer J. Thurecht,c   Jonathan W. Aylott,a   Weng C. Chan,a   Martin C. Garnetta  and  Cameron Alexander*a  

* Corresponding authors

a School of Pharmacy, University of Nottingham, University Park, Nottingham, UK
E-mail: cameron.alexander@nottingham.ac.uk
Tel: +44 (0) 115 846 7678

b Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan

c Australian Institute for Bioengineering and Nanotechnology, and Centre for Advanced Imaging, The University of Queensland, St. Lucia, Queensland 4072, Australia

Abstract

Polymer particles consisting of a biodegradable poly[lactide-co-glycolide] (PLGA) core and a thermoresponsive shell have been formulated to encapsulate the dye rhodamine 6G and the potent cytotoxic drug paclitaxel. Cellular uptake of these particles is significantly enhanced above the thermal transition temperature (TTT) of the polymer shells in the human breast carcinoma cell line MCF-7 as determined by flow cytometry and fluorescence microscopy. Paclitaxel-loaded particles display reduced and enhanced cytotoxicity below and above the TTT respectively compared to unencapsulated drug. The data suggests a potential route to enhanced anti-cancer efficacy through temperature-mediated cell targeting.

Graphical abstract: Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line

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Article information

DOI
https://doi.org/10.1039/C2BM00184E
Article type
Paper
Submitted
06 Dec 2012
Accepted
05 Jan 2013
First published
14 Jan 2013
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2013,1, 434-442

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Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line

S. R. Abulateefeh, S. G. Spain, K. J. Thurecht, J. W. Aylott, W. C. Chan, M. C. Garnett and C. Alexander, Biomater. Sci., 2013, 1, 434 DOI: 10.1039/C2BM00184E

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