A CO2-switchable polymer brush for reversible capture and release of proteins

Surjith Kumar; Xia Tong; Yves L. Dory; Martin Lepage; Yue Zhao

doi:10.1039/C2CC36284H

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A CO₂-switchable polymer brush for reversible capture and release of proteins†

Surjith Kumar,^ab Xia Tong,^a Yves L. Dory,*^a Martin Lepage*^b and Yue Zhao*^a

Author affiliations

* Corresponding authors

^a Département de chimie, Université de Sherbrooke, Sherbrooke, QC, Canada J1K 2R1
E-mail: yves.dory@usherbrooke.ca, yue.zhao@usherbrooke.ca

^b Département de médecine nucléaire et radiobiologie and Centre d’imagerie moléculaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
E-mail: martin.lepage@usherbrooke.ca

Abstract

We report on a polymer brush that can be switched between extended (hydrated) and collapsed (dehydrated) chain conformational states just by passing CO₂ and an inert gas like N₂ in solution alternately. This conformational change allows for reversible adsorption and release of a protein. In contrast to adding acids and bases for pH change, using gases as the trigger makes it possible to repeat the switching cycle many times without salt accumulation.

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Article information

DOI: https://doi.org/10.1039/C2CC36284H
Article type: Communication
Submitted: 29 Aug 2012
Accepted: 08 Nov 2012
First published: 09 Nov 2012

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Chem. Commun., 2013,49, 90-92

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A CO₂-switchable polymer brush for reversible capture and release of proteins

S. Kumar, X. Tong, Y. L. Dory, M. Lepage and Y. Zhao, Chem. Commun., 2013, 49, 90 DOI: 10.1039/C2CC36284H

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