Issue 39, 2013

Label-free in situ detection of individual macromolecular assemblies by surface enhanced Raman scattering

Abstract

We demonstrate label-free detection of lipid vesicles and polystyrene beads freely diffusing in aqueous solution using surface enhanced Raman scattering (SERS). The signals observed enable real-time identification and monitoring of individual particles interacting with the SERS substrate. SERS is demonstrated as a label-free method capable of monitoring transient species in solution on the millisecond time scale.

Graphical abstract: Label-free in situ detection of individual macromolecular assemblies by surface enhanced Raman scattering

Supplementary files

Article information

Article type
Communication
Submitted
24 Aug 2012
Accepted
17 Oct 2012
First published
17 Oct 2012

Chem. Commun., 2013,49, 4340-4342

Label-free in situ detection of individual macromolecular assemblies by surface enhanced Raman scattering

S. M. Asiala and Z. D. Schultz, Chem. Commun., 2013, 49, 4340 DOI: 10.1039/C2CC37268A

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