Label-free in situ detection of individual macromolecular assemblies by surface enhanced Raman scattering†
Abstract
We demonstrate label-free detection of lipid vesicles and polystyrene beads freely diffusing in aqueous solution using surface enhanced Raman scattering (SERS). The signals observed enable real-time identification and monitoring of individual particles interacting with the SERS substrate. SERS is demonstrated as a label-free method capable of monitoring transient species in solution on the millisecond time scale.
- This article is part of the themed collection: Emerging Investigators 2013