Issue 14, 2013

An efficient synthesis of optically active trifluoromethylaldiminesvia asymmetric biomimetic transamination

Abstract

This communication describes a chiral base-catalyzed asymmetric [1,3]-proton shift of trifluoromethyl ketimines, giving a wide variety of trifluoromethyl aldimines containing various functional groups with up to 94% ee.

Graphical abstract: An efficient synthesis of optically active trifluoromethyl aldimines via asymmetric biomimetic transamination

Supplementary files

Article information

Article type
Communication
Submitted
11 Oct 2012
Accepted
17 Dec 2012
First published
21 Dec 2012

Chem. Commun., 2013,49, 1404-1406

An efficient synthesis of optically active trifluoromethyl aldimines via asymmetric biomimetic transamination

M. Liu, J. Li, X. Xiao, Y. Xie and Y. Shi, Chem. Commun., 2013, 49, 1404 DOI: 10.1039/C2CC37423D

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