Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

Graeme J. Stasiuk; Helen Smith; Marzena Wylezinska-Arridge; Jordi L. Tremoleda; William Trigg; Sajinder Kaur Luthra; Veronique Morisson Iveson; Felicity N. E. Gavins; Nicholas J. Long

doi:10.1039/C2CC37460A

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Gd³⁺ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation†

Graeme J. Stasiuk,^ab Helen Smith,^b Marzena Wylezinska-Arridge,^c Jordi L. Tremoleda,^c William Trigg,^d Sajinder Kaur Luthra,^d Veronique Morisson Iveson,^d Felicity N. E. Gavins*^b and Nicholas J. Long*^a

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* Corresponding authors

^a Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
E-mail: n.long@imperial.ac.uk
Fax: +44 (0)20 7594 5804
Tel: +44 (0)20 7594 5781

^b Division of Brain Sciences, Department of Medicine, Imperial College London, Du Cane Road, London, UK
E-mail: f.gavins@imperial.ac.uk
Fax: +44 (0)20 7594 6548
Tel: +44 (0)20 7594 6586

^c Biological Imaging Centre, Imperial College London, Du Cane Road, London, UK

^d GE Healthcare, The Grove Centre, White Lion Road, Amersham, Buckinghamshire, UK

Abstract

Formyl Peptide Receptors (FPRs) are vital in the host inflammatory response, playing an important regulatory role in multiple diseases. A Gd(III) DOTA conjugate of cFLFLFK has been synthesised which targets and visualises FPR1 upon leukocytes in the inflammatory response via magnetic resonance imaging for the first time.

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Article information

DOI: https://doi.org/10.1039/C2CC37460A
Article type: Communication
Submitted: 12 Oct 2012
Accepted: 26 Nov 2012
First published: 27 Nov 2012

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Chem. Commun., 2013,49, 564-566

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Gd³⁺ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

G. J. Stasiuk, H. Smith, M. Wylezinska-Arridge, J. L. Tremoleda, W. Trigg, S. K. Luthra, V. M. Iveson, F. N. E. Gavins and N. J. Long, Chem. Commun., 2013, 49, 564 DOI: 10.1039/C2CC37460A

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Chemical Communications