Issue 3, 2013
From the journal:

Chemical Communications

Small neutral molecular carriers for selective carboxylate transport†

Cally J. E. Haynes,a   Stuart N. Berry,a   Joachim Garric,a   Julie Herniman,a   Jennifer R. Hiscock,a   Isabelle L. Kirby,a   Mark E. Light,a   Gregory Perkesa  and  Philip A. Gale*a  

* Corresponding authors

a Chemistry, University of Southampton, Southampton SO17 1BJ, UK
E-mail: philip.gale@soton.ac.uk
Fax: +44 (0)23 8059 6805
Tel: +44 (0)23 8059 3332

Abstract

A series of neutral thiourea receptors were found to mediate the antiport of chloride with a range of biologically relevant carboxylate anions across phospholipid bilayers. Simple structural modification of the carriers resulted in a change in the lactate/pyruvate transport selectivity.

Graphical abstract: Small neutral molecular carriers for selective carboxylate transport

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Article information

DOI
https://doi.org/10.1039/C2CC37468D
Article type
Communication
Submitted
12 Oct 2012
Accepted
14 Nov 2012
First published
23 Nov 2012

Chem. Commun., 2013,49, 246-248

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Small neutral molecular carriers for selective carboxylate transport

C. J. E. Haynes, S. N. Berry, J. Garric, J. Herniman, J. R. Hiscock, I. L. Kirby, M. E. Light, G. Perkes and P. A. Gale, Chem. Commun., 2013, 49, 246 DOI: 10.1039/C2CC37468D

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