Issue 7, 2013

Highly regioselective opening of zirconacyclopentadienes by remote coordination: concise synthesis of the furan core of the leupyrrins

Abstract

An efficient protocol for the highly regioselective opening of aliphatic zirconacyclopentadienes is reported. The one-pot process involves a zirconocene-mediated cyclization of 1,6-diynes and highly selective cleavage of the metallacycles with NBS and enables a concise synthesis of the tetrahydrofuran-core of the leupyrrins.

Graphical abstract: Highly regioselective opening of zirconacyclopentadienes by remote coordination: concise synthesis of the furan core of the leupyrrins

Supplementary files

Article information

Article type
Communication
Submitted
22 Oct 2012
Accepted
29 Nov 2012
First published
30 Nov 2012

Chem. Commun., 2013,49, 725-727

Highly regioselective opening of zirconacyclopentadienes by remote coordination: concise synthesis of the furan core of the leupyrrins

T. Debnar, S. Dreisigacker and D. Menche, Chem. Commun., 2013, 49, 725 DOI: 10.1039/C2CC37678D

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