Issue 14, 2013
From the journal:

Chemical Communications

Functional conversion of nickel-containing metalloproteinsvia molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase†

Yi Liu,a   Qingli Wang,b   Yaozhu Wei,a   Ying-Wu Lin,c   Wei Li,a   Ji-Hu Su,d   Zhen Wang,e   Yang Tian,e   Zhong-Xian Huanga  and  Xiangshi Tan*a  

* Corresponding authors

a Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China
E-mail: xstan@fudan.edu.cn
Fax: +86-21-65641740
Tel: +86-21-55664475

b College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China

c School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China

d Department of Modern Physics, University of Science and Technology of China, Hefei 230026, China

e Department of Chemistry, Tongji University, Shanghai, China

Abstract

Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O2˙− disproportionation, and exhibit impressive Ni-SOD activity.

Graphical abstract: Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC38224E
Article type
Communication
Submitted
14 Nov 2012
Accepted
02 Jan 2013
First published
03 Jan 2013

Chem. Commun., 2013,49, 1452-1454

Permissions

Request permissions

Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

Y. Liu, Q. Wang, Y. Wei, Y. Lin, W. Li, J. Su, Z. Wang, Y. Tian, Z. Huang and X. Tan, Chem. Commun., 2013, 49, 1452 DOI: 10.1039/C2CC38224E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements