Issue 32, 2013
From the journal:

Chemical Communications

A silver complex of N,N′-disubstituted cyclic thiourea as an anti-inflammatory inhibitor of IκB kinase†

Iris Wing-Shan Lin,a   Chun-Nam Lok,a   Kun Yana  and  Chi-Ming Che*a  

* Corresponding authors

a Department of Chemistry, State Key Laboratory of Synthetic Chemistry, HKU Shenzhen Institute of Research and Innovation, and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China
E-mail: cmche@hku.hk
Fax: +852 2857 1586
Tel: +852 2857 2154

Abstract

A silver complex of N,N′-disubstituted cyclic thiourea inhibits inflammatory cytokine-stimulated NF-κB activity via IκB kinase inactivation.

Graphical abstract: A silver complex of N,N′-disubstituted cyclic thiourea as an anti-inflammatory inhibitor of IκB kinase

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Article information

DOI
https://doi.org/10.1039/C3CC00063J
Article type
Communication
Submitted
04 Jan 2013
Accepted
27 Feb 2013
First published
27 Feb 2013

Chem. Commun., 2013,49, 3297-3299

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A silver complex of N,N′-disubstituted cyclic thiourea as an anti-inflammatory inhibitor of IκB kinase

I. W. Lin, C. Lok, K. Yan and C. Che, Chem. Commun., 2013, 49, 3297 DOI: 10.1039/C3CC00063J

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