Issue 40, 2013
From the journal:

Chemical Communications

A conjugated polymer–peptide hybrid system for prostate-specific antigen (PSA) detection†

Kangwon Lee,a   Suparna Mandal,b   Jinga Morry,c   Onnop Srivannavit,b   Erdogan Gularib  and  Jinsang Kim*abcd  

* Corresponding authors

a Materials Science and Engineering, University of Michigan, Ann Arbor, USA

b Chemical Engineering, University of Michigan, Ann Arbor, USA

c Biomedical Engineering, University of Michigan, Ann Arbor, USA

d Macromolecular Science and Engineering, University of Michigan, Ann Arbor, USA
E-mail: jinsang@umich.edu

Abstract

We developed fast and readily applicable microarray chips to detect PSA by designing a novel conjugated polymer (energy donor) and combining it with on-chip peptide synthesis. The selective cleavage of a probing peptide labelled with a dye or a quencher (energy acceptor) produced a fluorescence sensory signal via fluorescent energy resonance transfer (FRET).

Graphical abstract: A conjugated polymer–peptide hybrid system for prostate-specific antigen (PSA) detection

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Article information

DOI
https://doi.org/10.1039/C3CC00280B
Article type
Communication
Submitted
12 Jan 2013
Accepted
27 Mar 2013
First published
11 Apr 2013

Chem. Commun., 2013,49, 4528-4530

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A conjugated polymer–peptide hybrid system for prostate-specific antigen (PSA) detection

K. Lee, S. Mandal, J. Morry, O. Srivannavit, E. Gulari and J. Kim, Chem. Commun., 2013, 49, 4528 DOI: 10.1039/C3CC00280B

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