Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers

Dion van der Born; J. (Koos) D. M. Herscheid; Romano V. A. Orru; Danielle J. Vugts

doi:10.1039/C3CC37833K

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Efficient synthesis of [¹⁸F]trifluoromethane and its application in the synthesis of PET tracers†

Dion van der Born,^a J. (Koos) D. M. Herscheid,^a Romano V. A. Orru^b and Danielle J. Vugts*^ac

Author affiliations

* Corresponding authors

^a Department of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, Amsterdam, The Netherlands
E-mail: d.vugts@vumc.nl

^b Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Medicines and Systems, VU University, De Boelelaan 1083, Amsterdam, The Netherlands

^c Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, PO Box 7057, Amsterdam, The Netherlands

Abstract

A new strategy towards [¹⁸F]trifluoromethyl-containing compounds is developed. [¹⁸F]trifluoromethane is synthesised in a fast and efficient manner and subsequently used in the reaction with aldehydes and ketones forming [¹⁸F]trifluoromethyl carbinols in good yields.

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Article information

DOI: https://doi.org/10.1039/C3CC37833K
Article type: Communication
Submitted: 29 Oct 2012
Accepted: 25 Mar 2013
First published: 26 Mar 2013

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Chem. Commun., 2013,49, 4018-4020

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Efficient synthesis of [¹⁸F]trifluoromethane and its application in the synthesis of PET tracers

D. van der Born, J. (. D. M. Herscheid, R. V. A. Orru and D. J. Vugts, Chem. Commun., 2013, 49, 4018 DOI: 10.1039/C3CC37833K

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Chemical Communications