Issue 42, 2013
From the journal:

Chemical Communications

Oxidation of anticancer Pt(ii) complexes with monodentate phosphane ligands: towards stable but active Pt(iv) prodrugs†

María Ángeles Medrano,a   Amparo Álvarez-Valdés,a   Josefina Perles,b   Julio Lloret-Fillol,c   Sandra Muñoz-Galván,d   Amancio Carnero,d   Carmen Navarro-Ranninger*a  and  Adoración G. Quiroga*a  

* Corresponding authors

a Química Inorgánica, Universidad Autónoma de Madrid, 28049 Madrid, Spain
E-mail: adoracion.gomez@uam.es, carmen.navarro@uam.es
Fax: +34 914974833
Tel: +34 914974050

b SIDI, Universidad Autónoma de Madrid, 28049 Madrid, Spain

c Chemistry Department, Universitat de Girona, Girona-17071, Spain

d IBIS-HUVR-CSIC-Universidad de Sevilla, 41013 Sevilla, Spain

Abstract

The synthesis, characterization and cytotoxicity studies of two novel platinum(IV) complexes, trans-PtCl4(dma)(PPh3), 1, and trans-PtCl4(ipa)(PPh3), 2, where dma is dimethylamine and ipa is isopropylamine, have been carried out. Both complexes contain aliphatic amines trans to phosphane ligands as a good alternative to take advantage of the phosphane group lipophilicity and the stability of platinum(IV) to obtain more effective drugs. Moreover, the complexes are stable in solution and such stability allowed their antitumoral action and DNA interaction to be checked and proved.

Graphical abstract: Oxidation of anticancer Pt(ii) complexes with monodentate phosphane ligands: towards stable but active Pt(iv) prodrugs

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Article information

DOI
https://doi.org/10.1039/C3CC38416K
Article type
Communication
Submitted
22 Nov 2012
Accepted
03 Apr 2013
First published
04 Apr 2013

Chem. Commun., 2013,49, 4806-4808

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Oxidation of anticancer Pt(II) complexes with monodentate phosphane ligands: towards stable but active Pt(IV) prodrugs

M. Á. Medrano, A. Álvarez-Valdés, J. Perles, J. Lloret-Fillol, S. Muñoz-Galván, A. Carnero, C. Navarro-Ranninger and A. G. Quiroga, Chem. Commun., 2013, 49, 4806 DOI: 10.1039/C3CC38416K

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