Issue 20, 2013
From the journal:

Chemical Communications

Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells†

Kyoung-Ran Kim,ab   Da-Rae Kim,a   Taemin Lee,c   Ji Young Yhee,a   Byeong-Su Kim,c   Ick Chan Kwona  and  Dae-Ro Ahn*ad  

* Corresponding authors

a Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea
E-mail: drahn@kist.re.kr
Fax: +82 2 958 5909
Tel: +82 2 958 6645

b Department of Chemistry, College of Science, Yonsei University, Korea

c Interdisciplinary School of Green Energy and KIER-UNIST Advanced Center for Energy, Ulsan National Institute of Science and Engineering (UNIST), Ulsan 689-798, Republic of Korea

d KIST campus, University of Science (UST-KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea

Abstract

A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.

Graphical abstract: Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

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Article information

DOI
https://doi.org/10.1039/C3CC38693G
Article type
Communication
Submitted
24 Aug 2012
Accepted
18 Jan 2013
First published
21 Jan 2013

Chem. Commun., 2013,49, 2010-2012

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Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

K. Kim, D. Kim, T. Lee, J. Y. Yhee, B. Kim, I. C. Kwon and D. Ahn, Chem. Commun., 2013, 49, 2010 DOI: 10.1039/C3CC38693G

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