Issue 20, 2013

Organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position

Abstract

We report the first organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position. Importantly, 3-thiooxindoles and 3-alkoxyoxindoles are demonstrated to be reactive nucleophiles for the development of catalytic asymmetric reactions for the first time.

Graphical abstract: Organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position

Supplementary files

Article information

Article type
Communication
Submitted
09 Dec 2012
Accepted
19 Jan 2013
First published
23 Jan 2013

Chem. Commun., 2013,49, 2022-2024

Organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position

F. Zhou, X. Zeng, C. Wang, X. Zhao and J. Zhou, Chem. Commun., 2013, 49, 2022 DOI: 10.1039/C3CC38819K

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