A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells

Mingjie Wei; Peng Yin; Youming Shen; Lingli Zhang; Jianhui Deng; Shanyan Xue; Haitao Li; Bin Guo; Youyu Zhang; Shouzhuo Yao

doi:10.1039/C3CC39045D

A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells†

Mingjie Wei,^a Peng Yin,^a Youming Shen,^a Lingli Zhang,^a Jianhui Deng,^a Shanyan Xue,^a Haitao Li,^a Bin Guo,^a Youyu Zhang*^a and Shouzhuo Yao^a

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^a Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China
E-mail: zhangyy@hunnu.edu.cn
Fax: +86 73188872531
Tel: +86 75188865515

Abstract

A fluorescent probe (N-(4-methyl-2-oxo-2H-chromen-7-yl)-2,4-dinitrobenzenesulfonamide), which exhibits high selectivity to glutathione and cysteine among amino acids including sulphur-containing methionine and metal ions, was synthesized. The experiments demonstrate that the fluorescent probe is a reliable and specific probe for glutathione and cysteine in living cells.

Chemical Communications

A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells†

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A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells

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