Issue 35, 2013
From the journal:

Chemical Communications

A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion†

Javier Hernández-Gil,a   Sacramento Ferrer,*a   Elena Salvador,b   Javier Calvo,c   Enrique Garcia-Españab  and  Juan C. Mareque-Rivas*cd  

* Corresponding authors

a Departament de Química Inorgànica, Facultat de Farmàcia, Universitat de València, 46100-Burjassot, Valencia, Spain
E-mail: sacramento.ferrer@uv.es
Fax: +34-96-354-4960
Tel: +34-96-354-4521

b Departamento de Química, Inorgànica, Universidad de Valencia, Instituto de Ciencia Molecular, Edificio de Institutos de Paterna Apdo 22085, Valencia, Spain

c Cooperative Centre for Research in Biomaterials (CiC biomaGUNE), 20009 San Sebastián, Spain
E-mail: jmareque@cicbiomagune.es
Fax: +34 943 005301
Tel: +34 943 005313

d Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain

Abstract

The dinucleating ligand L (1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently cleaves DNA when M : L is 1 : 1 (M = Co(II) or Fe(III)) at pH 5.5–7.0, with free L being more active at acidic pH than when bound to Zn(II), Cu(II) or Ni(II) at neutral pH.

Graphical abstract: A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion

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Article information

DOI
https://doi.org/10.1039/C3CC39067E
Article type
Communication
Submitted
19 Dec 2012
Accepted
13 Mar 2013
First published
14 Mar 2013

Chem. Commun., 2013,49, 3655-3657

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A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion

J. Hernández-Gil, S. Ferrer, E. Salvador, J. Calvo, E. Garcia-España and J. C. Mareque-Rivas, Chem. Commun., 2013, 49, 3655 DOI: 10.1039/C3CC39067E

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