Issue 38, 2013
From the journal:

Chemical Communications

QD-filled micelles which combine SPECT and optical imaging with light-induced activation of a platinum(iv) prodrug for anticancer applications†

Carmen R. Maldonado,a   Nina Gómez-Blanco,b   Maite Jauregui-Osoro,c   Valerie G. Brunton,d   Luis Yateb  and  Juan C. Mareque-Rivas*be  

* Corresponding authors

a School of Chemistry, University of Edinburgh, Edinburgh, UK

b Cooperative Centre for Research in Biomaterials (CIC biomaGUNE), 20009 San Sebastián, Spain
E-mail: jmareque@cicbiomagune.es
Fax: +34 943 005301
Tel: +34 943 005313

c Division of Imaging Sciences & Biomedical Engineering, King's College London, St. Thomas' Hospital, London, UK

d Edinburgh Cancer Research Centre, Institute for Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK

e Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain

Abstract

The fac-[99mTc(OH2)3(CO)3]+ complex reacts with QD-filled micelles to create a bimodal SPECT–optical imaging probe which upon visible light irradiation generates cisplatin from an inert Pt(IV) prodrug.

Graphical abstract: QD-filled micelles which combine SPECT and optical imaging with light-induced activation of a platinum(iv) prodrug for anticancer applications

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Article information

DOI
https://doi.org/10.1039/C3CC39104C
Article type
Communication
Submitted
20 Dec 2012
Accepted
25 Mar 2013
First published
25 Mar 2013

Chem. Commun., 2013,49, 3985-3987

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QD-filled micelles which combine SPECT and optical imaging with light-induced activation of a platinum(IV) prodrug for anticancer applications

C. R. Maldonado, N. Gómez-Blanco, M. Jauregui-Osoro, V. G. Brunton, L. Yate and J. C. Mareque-Rivas, Chem. Commun., 2013, 49, 3985 DOI: 10.1039/C3CC39104C

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