Issue 26, 2013
From the journal:

Chemical Communications

Total synthesis of cyclic heptapeptide Rolloamide B†

Mirna El Khatib,a   Mohamed Elagawany,abc   Eray Çalışkan,a   Emily Faith Davis,a   Hassan M. Faidallah,d   Said A. El-fekyb  and  Alan R. Katritzky*ad  

* Corresponding authors

a Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
E-mail: katritzky@chem.ufl.edu

b Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig-44519, Egypt

c Department of Organic Chemistry, College of Pharmacy, Misr University for Science and Technology, Al-Motamayez District, 6th of October, P.O. Box: 77, Egypt

d Department of Chemistry, King Abdulaziz University, Jeddah, Saudi Arabia

Abstract

The first total synthesis of Rolloamide B, a cyclic proline-enriched heptapeptide, is reported. This work features solution phase benzotriazole-mediated peptide synthesis ligating native amino acids.

Graphical abstract: Total synthesis of cyclic heptapeptide Rolloamide B

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Article information

DOI
https://doi.org/10.1039/C3CC39291K
Article type
Communication
Submitted
30 Dec 2012
Accepted
23 Jan 2013
First published
24 Jan 2013

Chem. Commun., 2013,49, 2631-2633

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Total synthesis of cyclic heptapeptide Rolloamide B

M. E. Khatib, M. Elagawany, E. Çalışkan, E. F. Davis, H. M. Faidallah, S. A. El-feky and A. R. Katritzky, Chem. Commun., 2013, 49, 2631 DOI: 10.1039/C3CC39291K

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