Issue 50, 2013
From the journal:

Chemical Communications

Locked nucleic acid: tighter is different†

Jonathan K. Watts*a  

* Corresponding authors

a Department of Chemistry and Institute for Life Sciences, University of Southampton, UK
E-mail: j.k.watts@soton.ac.uk
Tel: +44 (0)23 8059 7679

Abstract

This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity and specificity of LNA, and these provide the main focus of the viewpoint.

Graphical abstract: Locked nucleic acid: tighter is different

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Article information

DOI
https://doi.org/10.1039/C3CC40340H
Article type
Viewpoint
Submitted
15 Jan 2013
Accepted
10 May 2013
First published
16 May 2013

Chem. Commun., 2013,49, 5618-5620

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Locked nucleic acid: tighter is different

J. K. Watts, Chem. Commun., 2013, 49, 5618 DOI: 10.1039/C3CC40340H

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