Issue 31, 2013
From the journal:

Chemical Communications

Resonance Raman scattering of catalytic beacons for DNA detection†

Kristy S. McKeating,a   Duncan Grahama  and  Karen Faulds*a  

* Corresponding authors

a Centre for Molecular Nanometrology, West CHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral St., Glasgow, UK
E-mail: Karen.faulds@strath.ac.uk
Tel: +44 (0)141 548 2507

Abstract

A novel method for analysing the catalytic action of a DNAzyme is reported. Resonance Raman scattering (RRS) is shown to successfully monitor the oxidation of two different peroxidase substrates and has been implemented in an assay for the detection of target DNA, providing a more sensitive method of analysis than current colorimetric techniques.

Graphical abstract: Resonance Raman scattering of catalytic beacons for DNA detection

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Article information

DOI
https://doi.org/10.1039/C3CC40346G
Article type
Communication
Submitted
15 Jan 2013
Accepted
06 Mar 2013
First published
14 Mar 2013

Chem. Commun., 2013,49, 3206-3208

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Resonance Raman scattering of catalytic beacons for DNA detection

K. S. McKeating, D. Graham and K. Faulds, Chem. Commun., 2013, 49, 3206 DOI: 10.1039/C3CC40346G

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