Issue 31, 2013
From the journal:

Chemical Communications

Reactions of organolithiums with dialkyl oxalates. A flow microreactor approach to synthesis of functionalized α-keto esters†

Aiichiro Nagaki,a   Daisuke Ichinaria  and  Jun-ichi Yoshida*a  

* Corresponding authors

a Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, 615-8510 Kyoto, Japan
E-mail: yoshida@sbchem.kyoto-u.ac.jp
Fax: +81-75-383-2725
Tel: +81-75-383-2726

Abstract

Reactions of functionalized aryllithiums with dialkyl oxalates were achieved using a flow microreactor to obtain α-keto esters with high selectivity by virtue of fast 1 : 1 micromixing.

Graphical abstract: Reactions of organolithiums with dialkyl oxalates. A flow microreactor approach to synthesis of functionalized α-keto esters

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Article information

DOI
https://doi.org/10.1039/C3CC40392K
Article type
Communication
Submitted
17 Jan 2013
Accepted
28 Feb 2013
First published
13 Mar 2013

Chem. Commun., 2013,49, 3242-3244

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Reactions of organolithiums with dialkyl oxalates. A flow microreactor approach to synthesis of functionalized α-keto esters

A. Nagaki, D. Ichinari and J. Yoshida, Chem. Commun., 2013, 49, 3242 DOI: 10.1039/C3CC40392K

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