Issue 32, 2013

A cascade approach to fused indolizinones through Lewis acid–copper(i) relay catalysis

Abstract

A relay catalytic cascade process involving Lewis acid triggered ring-opening of cyclopropyl ketones with nitriles, the copper(I)-catalyzed Ritter process, and acid-promoted N-acyliminium ion cyclization is described, which efficiently provides thieno-, furano-, and benzo-indolizinones in moderate to good yields.

Graphical abstract: A cascade approach to fused indolizinones through Lewis acid–copper(i) relay catalysis

Supplementary files

Article information

Article type
Communication
Submitted
25 Jan 2013
Accepted
05 Mar 2013
First published
06 Mar 2013

Chem. Commun., 2013,49, 3351-3353

A cascade approach to fused indolizinones through Lewis acid–copper(I) relay catalysis

H. Huang, X. Ji, W. Wu and H. Jiang, Chem. Commun., 2013, 49, 3351 DOI: 10.1039/C3CC40643A

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