Issue 40, 2013
From the journal:

Chemical Communications

An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers†

Aurore Fraix,a   Noufal Kandoth,a   Ilse Manet,*b   Venera Cardile,c   Adriana C. E. Graziano,c   Ruxandra Grefd  and  Salvatore Sortino*a  

* Corresponding authors

a Laboratory of Photochemistry, Department of Drug Sciences, University of Catania, I-95125 Catania, Italy
E-mail: ssortino@unict.it

b Istituto per la Sintesi Organica e la Fotoreattività-CNR, Bologna, Italy
E-mail: ilse.manet@isof.cnr.it

c Department of Bio-Medical Sciences, Physiology Division, University of Catania, I-95125 Catania, Italy

d UMR CNRS 8612, Faculty of Pharmacy, Paris Sud University, 92290 Châtenay-Malabry, France

Abstract

A multifunctional nanoplatform with four-in-one photoresponsive functionalities has been achieved through the co-encapsulation of two chromo-fluorogenic components within biocompatible polymeric nanoparticles. This engineered nanoconstruct efficiently delivers different photosensitizers in melanoma cells, which can be detected through their dual-color fluorescence, and induces amplified cell mortality due to the simultaneous photogeneration of singlet oxygen and nitric oxide.

Graphical abstract: An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers

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Article information

DOI
https://doi.org/10.1039/C3CC40714D
Article type
Communication
Submitted
28 Jan 2013
Accepted
28 Mar 2013
First published
28 Mar 2013

Chem. Commun., 2013,49, 4459-4461

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An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers

A. Fraix, N. Kandoth, I. Manet, V. Cardile, A. C. E. Graziano, R. Gref and S. Sortino, Chem. Commun., 2013, 49, 4459 DOI: 10.1039/C3CC40714D

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