Issue 43, 2013
From the journal:

Chemical Communications

Iodine-mediated intramolecular amination of ketones: the synthesis of 2-acylindoles and 2-acylindolines by tuning N-protecting groups†

Wen-Chao Gao,a   Shan Jiang,a   Ruo-Lin Wanga  and  Chi Zhang*a  

* Corresponding authors

a State Key Laboratory of Elemento-Organic Chemistry, The Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China
E-mail: zhangchi@nankai.edu.cn
Fax: +8622-23503627

Abstract

A general method for constructing both 2-acylindoles and 2-acylindolines via I2-mediated intramolecular C–N bond formation is presented, and the selective formation of either 2-acylindoles or 2-acylindolines just depends on the nitrogen protecting groups used in the same substrate skeletons.

Graphical abstract: Iodine-mediated intramolecular amination of ketones: the synthesis of 2-acylindoles and 2-acylindolines by tuning N-protecting groups

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Article information

DOI
https://doi.org/10.1039/C3CC40797G
Article type
Communication
Submitted
30 Jan 2013
Accepted
27 Feb 2013
First published
27 Feb 2013

Chem. Commun., 2013,49, 4890-4892

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Iodine-mediated intramolecular amination of ketones: the synthesis of 2-acylindoles and 2-acylindolines by tuning N-protecting groups

W. Gao, S. Jiang, R. Wang and C. Zhang, Chem. Commun., 2013, 49, 4890 DOI: 10.1039/C3CC40797G

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