Issue 40, 2013
From the journal:

Chemical Communications

CuCl-catalyzed orthotrifluoromethylation of arenes and heteroarenes with a pivalamido directing group†

Shangjun Cai,a   Chao Chen,*a   Zelin Suna  and  Chanjuan Xi*ab  

* Corresponding authors

a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: chenchao01@mails.tsinghua.edu.cn, cjxi@tsinghua.edu.cn
Tel: +86-10-62773684

b State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Abstract

The CuCl catalyzed direct trifluoromethylation of sp2 C–H bonds has been realized, using the Togni reagent as the CF3 source. This reaction achieves the goal of regio-selectively converting C–H into C–CF3 with ecological and readily available starting materials.

Graphical abstract: CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group

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Article information

DOI
https://doi.org/10.1039/C3CC41331D
Article type
Communication
Submitted
20 Feb 2013
Accepted
21 Mar 2013
First published
25 Mar 2013

Chem. Commun., 2013,49, 4552-4554

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CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group

S. Cai, C. Chen, Z. Sun and C. Xi, Chem. Commun., 2013, 49, 4552 DOI: 10.1039/C3CC41331D

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