Issue 43, 2013
From the journal:

Chemical Communications

A real-time colorimetric assay for label-free detection of microRNAs down to sub-femtomolar levels

Wei Shen,a   Huimin Deng,a   Yuqian Rena  and  Zhiqiang Gao*a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, Singapore 117543
E-mail: chmgaoz@nus.edu.sg
Fax: +65 6779-1691
Tel: +65 6516-3887

Abstract

A real-time colorimetric assay utilizing gold nanoparticle networks and a duplex-specific nuclease (DSN) for label-free detection of microRNAs is proposed. Excellent sensitivity and selectivity were accomplished through the engagement of the DSN and a cumulative signal amplification process.

Graphical abstract: A real-time colorimetric assay for label-free detection of microRNAs down to sub-femtomolar levels

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Article information

DOI
https://doi.org/10.1039/C3CC41565A
Article type
Communication
Submitted
01 Mar 2013
Accepted
08 Apr 2013
First published
22 Apr 2013

Chem. Commun., 2013,49, 4959-4961

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A real-time colorimetric assay for label-free detection of microRNAs down to sub-femtomolar levels

W. Shen, H. Deng, Y. Ren and Z. Gao, Chem. Commun., 2013, 49, 4959 DOI: 10.1039/C3CC41565A

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