Issue 48, 2013
From the journal:

Chemical Communications

Asymmetric amplification in the catalytic enantioselective 1,2-addition of Grignard reagents to enones†

Francesca Caprioli,a   Ashoka V. R. Madduri,a   Adriaan J. Minnaard*a  and  Syuzanna R. Harutyunyan*a  

* Corresponding authors

a Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, Groningen, The Netherlands
E-mail: s.harutyunyan@rug.nl, a.j.minnaard@rug.nl
Fax: +31-50-363-4296
Tel: +31-50-363-3539

Abstract

Large asymmetric amplification originating from solubility differences between the enantiopure and the racemic catalyst is observed in the addition of Grignard reagents to enones. This behaviour is not reaction or catalyst specific and is observed for metal complexes of a variety of chiral diphosphine ligands, extensively used in asymmetric catalysis.

Graphical abstract: Asymmetric amplification in the catalytic enantioselective 1,2-addition of Grignard reagents to enones

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC41892H
Article type
Communication
Submitted
13 Mar 2013
Accepted
22 Apr 2013
First published
23 Apr 2013

Chem. Commun., 2013,49, 5450-5452

Permissions

Request permissions

Asymmetric amplification in the catalytic enantioselective 1,2-addition of Grignard reagents to enones

F. Caprioli, A. V. R. Madduri, A. J. Minnaard and S. R. Harutyunyan, Chem. Commun., 2013, 49, 5450 DOI: 10.1039/C3CC41892H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements