Issue 45, 2013
From the journal:

Chemical Communications

A universal biosensor for multiplex DNA detection based on hairpin probe assisted cascade signal amplification†

Jie Liu,a   Lingbo Chen,ab   Puchang Lie,a   Boying Duna  and  Lingwen Zeng*a  

* Corresponding authors

a Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
E-mail: zeng6@yahoo.com
Fax: +86 20 32015245
Tel: +86 20 32015312

b School of Life Sciences, Anhui University, Hefei 230601, P.R. China

Abstract

A hairpin DNA probe mediated cascade signal amplification method was developed for visual and rapid DNA analysis with a detection limit of 100 aM. The implementation of tag/anti-tag DNA and gold nanoparticle reporters permits a universal platform for multiplex genotyping without instrumentation.

Graphical abstract: A universal biosensor for multiplex DNA detection based on hairpin probe assisted cascade signal amplification

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Article information

DOI
https://doi.org/10.1039/C3CC41941J
Article type
Communication
Submitted
15 Mar 2013
Accepted
09 Apr 2013
First published
10 Apr 2013

Chem. Commun., 2013,49, 5165-5167

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A universal biosensor for multiplex DNA detection based on hairpin probe assisted cascade signal amplification

J. Liu, L. Chen, P. Lie, B. Dun and L. Zeng, Chem. Commun., 2013, 49, 5165 DOI: 10.1039/C3CC41941J

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