Palladium-catalysed aerobic oxidative Heck-type alkenylation of Csp3–H for pyrrole synthesis

Lingkui Meng; Kun Wu; Chao Liu; Aiwen Lei

doi:10.1039/C3CC42307G

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Palladium-catalysed aerobic oxidative Heck-type alkenylation of Csp³–H for pyrrole synthesis†

Lingkui Meng,^a Kun Wu,^a Chao Liu^a and Aiwen Lei*^ab

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* Corresponding authors

^a College of Chemistry and Molecular Sciences, Wuhan University, P. R. China
E-mail: aiwenlei@whu.edu.cn
Tel: +86-27-68754672

^b Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China

Abstract

The first palladium-catalysed aerobic oxidative intramolecular alkenylation of Csp³–H bonds was described. The reaction conditions were mild and molecular oxygen was used as the terminal oxidant. Kinetic studies showed that the Csp³–H metallation step was a slow step.

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Article information

DOI: https://doi.org/10.1039/C3CC42307G
Article type: Communication
Submitted: 29 Mar 2013
Accepted: 07 May 2013
First published: 09 May 2013

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Chem. Commun., 2013,49, 5853-5855

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Palladium-catalysed aerobic oxidative Heck-type alkenylation of Csp³–H for pyrrole synthesis

L. Meng, K. Wu, C. Liu and A. Lei, Chem. Commun., 2013, 49, 5853 DOI: 10.1039/C3CC42307G

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Chemical Communications