Molecularly-imprinted nanoparticles that recognize Naja mossambica cytotoxins: binding studies and biological effects

Samantha Piszkiewicz; Evan A. Kirkbride; Nicolai Doreng-Stearns; Blake R. Henderson; Melissa A. Lenker; Erika Tang; Laura H. Kawashiri; Curtis S. Nichols; Sebastian C. Moore; Steven G. Sogo

doi:10.1039/C3CC42394H

Molecularly-imprinted nanoparticles that recognize Naja mossambica cytotoxins: binding studies and biological effects†

Samantha Piszkiewicz,^a Evan A. Kirkbride,^a Nicolai Doreng-Stearns,^a Blake R. Henderson,^a Melissa A. Lenker,^a Erika Tang,^a Laura H. Kawashiri,^a Curtis S. Nichols,^a Sebastian C. Moore^a and Steven G. Sogo*^a

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^a Department of Chemistry, Laguna Beach High School, California 92651, USA
E-mail: ssogo@lbusd.org
Fax: +1-949-497-7766
Tel: +1-949-497-7750

Abstract

We report the development of molecularly imprinted polyacrylamide nanoparticles that bind to and neutralize the activity of cytotoxins present in the venom of the Mozambique Spitting Cobra (Naja mossambica mossambica). The binding activity of these nanoparticles is avid and specific. These findings hold promise for the development of a synthetic antivenom.

Chemical Communications

Molecularly-imprinted nanoparticles that recognize Naja mossambica cytotoxins: binding studies and biological effects†

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Molecularly-imprinted nanoparticles that recognize Naja mossambica cytotoxins: binding studies and biological effects

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