Issue 50, 2013
From the journal:

Chemical Communications

Thiol–ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors†

Mohamed-Chiheb Saada,a   Joanna Ombouma,a   Jean-Louis Montero,a   Claudiu T. Supuran*b  and  Jean-Yves Winum*a  

* Corresponding authors

a Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM1-UM2, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France
E-mail: jean-yves.winum@univ-montp2.fr
Fax: +33 (0)467144344
Tel: +33 (0)467147234

b Università degli Studi di Firenze, Neurofarba Department, Section of Pharmaceutical Sciences, Via Ugo Schiff 6, Florence, Italy
E-mail: claudiu.supuran@unifi.it
Fax: +39-055-4573385
Tel: +39-055-4573005

Abstract

Thiol–ene click chemistry has been applied for obtaining sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors incorporating sugar moieties. Most of these new compounds were moderate CA I inhibitors, effective CA II inhibitors, and low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms CA IX and XII.

Graphical abstract: Thiol–ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors

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Article information

DOI
https://doi.org/10.1039/C3CC42541J
Article type
Communication
Submitted
08 Apr 2013
Accepted
30 Apr 2013
First published
30 Apr 2013

Chem. Commun., 2013,49, 5699-5701

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Thiol–ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors

M. Saada, J. Ombouma, J. Montero, C. T. Supuran and J. Winum, Chem. Commun., 2013, 49, 5699 DOI: 10.1039/C3CC42541J

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