Issue 67, 2013

Direct N-cyclopropylation of secondary acyclic amides promoted by copper

Abstract

The N-cyclopropylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper system. The corresponding tertiary acyclic amides, which constitute a wide family of biologically active compounds, have been obtained in good to excellent yields.

Graphical abstract: Direct N-cyclopropylation of secondary acyclic amides promoted by copper

Supplementary files

Article information

Article type
Communication
Submitted
09 Apr 2013
Accepted
18 Jun 2013
First published
17 Jul 2013

Chem. Commun., 2013,49, 7412-7414

Direct N-cyclopropylation of secondary acyclic amides promoted by copper

E. Racine, F. Monnier, J. Vors and M. Taillefer, Chem. Commun., 2013, 49, 7412 DOI: 10.1039/C3CC42575D

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