Issue 67, 2013
From the journal:

Chemical Communications

Photochirogenesis with mutant human serum albumins: enantiodifferentiating photocyclodimerization of 2-anthracenecarboxylate†

Masaki Nishijima,a   Hanako Kato,b   Gaku Fukuhara,b   Cheng Yang,bc   Tadashi Mori,b   Toru Maruyama,d   Masaki Otagiri*de  and  Yoshihisa Inoue*b  

* Corresponding authors

a Office for University-Industry Collaboration, Osaka University, Yamada-oka, Suita, Japan

b Department of Applied Chemistry, Osaka University, Yamada-oka, Suita, Japan
E-mail: inoue@chem.eng.osaka-u.ac.jp
Fax: +81-6-6879-7923
Tel: +81-6-6879-7920

c College of Chemistry, Sichuan University, Chengdu 610064, P. R. China

d Graduate School of Pharmaceutical Science, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan

e Faculty of Pharmaceutical Science, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan
E-mail: otagirim@ph.sojo-u.ac.jp
Fax: +81-96-326-5048
Tel: +81-96-326-3887

Abstract

Mutant human serum albumins accelerated the photocyclodimerization of 2-anthracenecarboxylate to afford chiral cyclodimers in 75–85% enantiomeric excesses, revealing that the mutations to impair non-productive sites 1 and/or 2 enhanced the substrate binding to site 3 without seriously damaging its inherently high photochirogenic ability.

Graphical abstract: Photochirogenesis with mutant human serum albumins: enantiodifferentiating photocyclodimerization of 2-anthracenecarboxylate

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Article information

DOI
https://doi.org/10.1039/C3CC42656D
Article type
Communication
Submitted
11 Apr 2013
Accepted
21 Jun 2013
First published
24 Jun 2013

Chem. Commun., 2013,49, 7433-7435

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Photochirogenesis with mutant human serum albumins: enantiodifferentiating photocyclodimerization of 2-anthracenecarboxylate

M. Nishijima, H. Kato, G. Fukuhara, C. Yang, T. Mori, T. Maruyama, M. Otagiri and Y. Inoue, Chem. Commun., 2013, 49, 7433 DOI: 10.1039/C3CC42656D

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