Issue 73, 2013
From the journal:

Chemical Communications

Crosstalk between Cu(i) and Zn(ii) homeostasis via Atx1 and cognate domains†

Adriana Badarau,a   Arnaud Baslé,a   Susan J. Firbanka  and  Christopher Dennison*a  

* Corresponding authors

a Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne, UK
E-mail: christopher.dennison@ncl.ac.uk

Abstract

The copper metallochaperone Atx1 and the N-terminal metal-binding domain of a copper-transporting ATP-ase can form tight Zn(II)-mediated hetero-complexes in both cyanobacteria and humans. Copper and zinc homeostasis could be linked by metal binding to these CXXC-containing proteins.

Graphical abstract: Crosstalk between Cu(i) and Zn(ii) homeostasis via Atx1 and cognate domains

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Article information

DOI
https://doi.org/10.1039/C3CC42709A
Article type
Communication
Submitted
12 Apr 2013
Accepted
24 Jul 2013
First published
25 Jul 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 8000-8002

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Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate domains

A. Badarau, A. Baslé, S. J. Firbank and C. Dennison, Chem. Commun., 2013, 49, 8000 DOI: 10.1039/C3CC42709A

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